CANCER SCREENING & TREATMENT CENTER OF NEVADA
CENTURY WELLNESS CLINIC

Presents
Outcome Based
POLY-MVA CLINICAL STUDY
2004


POLY- MVA “Outcome based” CLINICAL STUDY
STUDY BEGAN: 01/2004
SPONSORS: AMARC ENTERPRISES, INC.; GARNETT-MCKEEN LABORATORY, INC.;
FOUNDATION FOR THE ADVANCEMENT IN CANCER RESEARCH

# CASES STATUS PERCENTAGE
83 ORAL ONLY 77%
23 IV + ORAL 23%
8 DISCONTINUED 7%
22 EXPIRED 20%
10 TOO EARLY 9%
40 NON-EVAL 37%
66 EVALUABLE 63%

POLY- MVA: THE PRODUCT

  1. POLY- A patented palladium lipoic acid complex
  2. MVA: Minerals: Molybdenum, Rhodium & Ruthenium
    Vitamins: B1, B2, B12
    Amino Acids: Formyl-Methionine, N-acetyl cysteine,
  3. Palladium (PL) is a rare mineral often combined with platinum in jewelry. M.W. 106 found in nature alloyed with platinum,copper and nickel. Highly conductive metal.
  4. ALA a super antioxidant and detoxifier. It is both water and fat soluble. It is an effective chelator with heavy metals.

POLY- MVA: PROVEN ACTIONS

  1. Aid in cellular energy production
  2. Support liver detoxification
  3. Protect cell integrity
  4. Acts as a heavy metal chelator
  5. Acts as a powerful antioxidant
  6. Support nerve and neurotransmittal function
  7. Enhance WBC function
  8. Assists in improving energy flow along meridians
  • The original family member of palladium lipoic complex, DNA Reductase, was named for its ability to shunt electron energy from itself to DNA via the mitochondria. [By donating electrons DNA can be reduced, and thus oxidation in general , as well as a result of radiation and carcinogens, can be combated.]
  • The mineral Palladium was chosen for a specific reason. For one it has a common resonance frequency with DNA whereby electron transfer between the molecules is facilitated. Also, Palladium can be permanently bound to alpha lipoic acid.
  • Palladium Lipoic acid (LAPd) complex’s differ from free radical scavengers (e.g. ?lipoic acid) because they are irreversibly bound together resulting in a molecule that is both fat and water soluble. Poly MVA is a polymer (liquid crystal) rather than a single molecule. Therefore, the polymer provides a unified redox (will accept charge and donate charge) reaction.
SUMMARY - It is a much more effective energy transferring molecule.
  • Their ability to both quench radical species and shunt electrons down the electron transport chain also make them effective in limiting ischemic damage (Antonawich, et al., Experimental Neurology, 2004; Antonawich and Welicky).
  • While it has the ability to shuttle energy to each cell, the selective vulnerability of the cancer cell is due to its disrupted metabolic STATE.
  • Safety data, including Ames and toxicity tests has been done and has shown complete safety. (Pharmakon and Calvert Labs)

POLY- MVA: PROTOCOL

Pts on standard chemotherapy with Poly- MVA 58/106 = 54%
Pts on IPT with Poly-MVA 2/106 = 2%
Pts on alternative therapy alone 33/106 = 31%
Pts on hormonal therapy alone 19/106 = 13%

POLY- MVA: CLINICAL TRIAL

  • Overall Response Rates (ORR)
  • ORR minus early expirations, discontinuations, too early to evaluate
  • Complete responses (CR) 14/66 = 21%
  • Partial Responses (PR) 39/66 = 56%
  • Overall Response Rate (ORR) CR + PR = 77%
  • Progressive Disease (PD) = 23%

POLY-MVA PROTOCOL BY TUMOR TYPE


TUMOR NUMBER
AML 2
BLADDER 1
BRAIN 2
BREAST 21
COLORECTAL 12
ESOPHAGUS 2
HEAD / NECK 4
LUNG 19
MELANOMA 4
MYELOMA 1
NHL 4
OVARY 2
PANCREAS 2
PROSTATE 15
RENAL 3
SARCOMA 3

TOTAL NUMBER OF CASES 106


POLY-MVA PROTOCAL
TUMOR RESPONSE RATES OF FOUR MAJOR CANCERS

CANCER TYPE STAGE NUMBER
OF CASES
CR % PR %
BREAST IV 21 0 0% 12 57%
*CRC IV 12 0 0% 1 8%
LUNG IV 19 4 21% 7 36%
**PROS IV 16 6 40% 5 33%

*   Worst Response
** Best Response


IV POLY-MVA RESULTS

PATIENT SEX TUMOR TYPE START DATE STATUS DURATION
6019 M MELANOMA IV 06/04 PD  
7001 F BLADDER I 07/04 PR > 3 MOS
6009 F BREAST IV 06/04 PR > 4 MOS
5003 F BREAST IV 05/04 PR > 4 MOS
8006 M NHL IV 06/04 PR > 4 MOS
8003 F LUNG IV 08/04 PD  
6000 M STOMACH IV 06/04 PR > 3 MOS
2007 M PROSTATE IV 02/04 PR > 7 MOS
6010 F LUNG IV 06/04 PR > 3 MOS
5017 F BREAST IV 05/04 PR > 4 MOS
6005 F LUNG IV 06/04 PR > 3 MOS
TO F BREAST IV 07/04 PR > 3 MOS
4000 F SARCOMA IV 04/04 PR > 5 MOS
5001 F BREAST IV 05/04 PR > 4 MOS
6011 F CRC IV 06/04 PD  
5010 F COLON IV 05/04 EX  
5007 F LUNG IV 05/04 CR > 5 MOS
7000 M H/N IV 07/04 PR > 3 MOS
7010 M ESOP IV 07/04 PR > 3 MOS
7007 M BRAIN IV 06/04 PR > 4 MOS
8003 M MHL IV 08/04 PR > 2 MOS
8006 F BREAST IV 08/04 PR > 2 MOS
CR COMPLETE REMISSION
PR PARTIAL REMISSION
PD PROGRESSIVE DISEASE
EX EXPIRED

POLY-MVA CLINICAL PROTOCOL SAMPLE CASES

PT SX TUMOR START DATE RESP CLINICAL SUMMARY
3002 F LUNG IV 03/04 PR 60 YO BF BILAT LUNG METS STABLE CXR, STABLE MARKERS
4012 M LUNG IV 04/04 CR 78 YO WM LUNG AND SKIN METS CLEAR CXR, MARKERS NL
5011 M PROSTATE IV 05/04 CR 60 YO WM NORMAL PSA, NORMAL SCANS
1010 M H/N IV 01/04 CR 72 YO WM NORMAL PE, NORMAL MRI
4008 F BREAST IV 04/04 PR 59 YO WF IMPROVED LUNG AND CW METS, IMPROVED MARKERS
4015 F LUNG IV 04/04 PR 49 YOWF STABLE CXR, STABLE MARKERS
5001 M NHL IV 05/04 CR 61 YO WM NO ADENOPATHY, NORMAL MARKERS
4001 F SARCOMA IV 04/04 PR 19 YO WF IMPROVED CXR, NEG SCANS
1005 M PROSTATE IV 01/04 PR 76 YO WM REFRACTORY CA , PSA DECREASED 2,4OO TO 1,000 STABLE DISEASE
2003 F BREAST IV 02/04 PR 46 YO WF STABLE CXR/SCANS/MARKERS

Adverse effects of IV / ORAL Poly-MVA
NAUSEA / VOMITING 0%
DIARRHEA <5%
SHORT OF BREATH <5% (40 ml only)
SKIN RASH 0%
ABN LIVER TESTS 0%
ABN RENAL TESTS 0%
TRANSFUSION REACTIONS 0%

POLY-MVA
Patients who respond to
IV Poly-MVA
On alternative therapy only:
10/24 = 42%

Poly-MVA—STUDY SUMMARY

  • This Clinical Oncology “Outcome Based” study over a nine month period was conducted on Stage IV patients with multiple cancer origins.
  • The Study was voluntary and not double-blinded or placebo controlled.
  • The major parameters included:
    CR – All Clinical disease in Remission
    PR – Greater than 50% reduction in tumor mass/markers
    PD – Progressive disease, no cessation in tumor growth
  • A 77% overall response rate (ORR) combining CR +PR > 3months
  • No significant adverse toxicities-IV or oral.
  • Significant response rate in patients not on conventional chemotherapy or hormonal therapy – 42%


PolyMVA: Model for Cancer Destruction

Palladium Lipoic Acid (PLA) acts by transferring electron charge from membrane fatty acids to DNA and mitochondria. Approximately a quarter volt of energy is utilized by the mitochondria, of normal cells, to combine with oxygen to form water in coupled reactions to produce energy (ATP) for normal growth and healing.

In anaerobic or severely hypoxic cell systems, however, such as in certain malignant tumors and protozoa, the electron energy can not transfer to mitochondrial oxygen. Instead a sequence of ionization begins in the cell membrane and in the mitochondrial membrane. These ionization reactions begins with membrane blebbing and matures into a cascade of reactions, known collectively as apoptosis, in which mitochondrial proteins are released, facilitating the activation of cell destructive enzymes. These reactions lead to the eventual death of the anaerobic or hypoxic (cancer) cell and provide a theoretical model for treatment studies.

Over 800 physicians who use Poly-MVA cannot be wrong. Dr. James Forsythe, Board Certified Oncologist has recently presented his 125 case study of stage 4 cancer patients with a 77 percent response rate using Poly-MVA. Non-Hodgkins Lymphoma, Ovarian, Brain, Pancreatic, Breast, Multiple Myeloma, Leukemia and Lung cancers, many with wide metastasis responded. A 23 percent FULL REVERSAL statistic is unheard of in these type of cancers, add to that 54 percent who had partial remissions and improving and you have a miracle in the making. All this with an average of 6 months of treatment. Yes that is what Dr. Forsythe reported – 77 percent response rate in terminal patients! Are you ready to assist the many cancer patients in your practice by using a non-toxic discovery ?



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